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. 2023 Mar 30;18:14. doi: 10.1186/s13062-023-00368-8

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — circACTR2 is decreased in GEM-resistant PC cells

A Scatter plot shows the up-regulated and down-regulated circRNAs in acquired GEM-resistant SW1990/GZ PC cells compared with parental SW1990 cells. B The differentially expressed circRNAs with most change fold in SW1990/GZ PC cells compared with SW1990 cells were validated by qRT-PCR. C Relative cell viability of a panel of PC cell lines treated with increased concentration of gemcitabine for 72 h was determined by CCK-8 assay. D circACTR2 expression was determined in a panel of PC cell lines by qRT-PCR assay. E Gene Ontology analysis and F pathway analysis of circACTR2 based on microarray profile data. *P < 0.05 and **P < 0.01 vs. SW1990/GZ; ^#P < 0.05 and ^##P < 0.01 vs. Panc-1