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. 2023 Mar 30;18:14. doi: 10.1186/s13062-023-00368-8

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — circACTR2 is negatively associated with aggressive cell phenotype and poor prognosis

A circACTR2 information from the UCSC Genome Browser. The amplified product was sequenced using Sanger sequencing to validate the circularized junction of circACTR2. B qRT-PCR analysis of circACTR2 and ACTR2 mRNA in SW1990 cells with actinomycin D treatment for 30 min at 37 °C. C qRT-PCR analysis of circACTR2 and ACTR2 mRNA in SW1990 cells treated with RNase R. D FISH images showed that circACTR2 labeled with Cy3 (red) was mainly distributed in the cytoplasm of SW1990 cells. The nuclei was stained with DAPI (blue). Scale bar, 25 μm. E Representative images of circACTR2 expression in PC tissues were detected by ISH. F Percentages of specimen with low or high expression of circACTR2 in PC compared with NP tissues and in PC tissues with different pathological grade. G Kaplan-Meier’s analyze of correlation between circACTR2 expression level and overall survival of patients with PC (n = 99, p < 0.01, log-rank test). *P < 0.05; **P < 0.01