Table 6.
Subgroup meta-analysis of main outcomes in patients with OSA in asthma group and non-asthma group
| Outcomes and subgroups | No. of studies | Population | WMD | 95%CI | I2 (%) | PH | Statistical model | PZ | Between-group P value |
|---|---|---|---|---|---|---|---|---|---|
| AHI (events/hour) | |||||||||
| All | 9 | 9540 | 0.47 | − 1.59, 2.52 | 65.9 | 0.003 | Random | 0.656 | – |
| Age | |||||||||
| Adult | 7 | 9434 | 0.72 | − 1.95, 3.38 | 74.2 | 0.001 | Random | 0.599 | 0.670 |
| Children | 2 | 106 | − 0.08 | − 2.61, 2.44 | 0 | 0.703 | 0.948 | – | |
| Severity of OSA | |||||||||
| AHI ≥ 1 or 5/h | 5 | 3801 | 0.27 | − 1.97, 2.50 | 43.0 | 0.135 | Random | 0.686 | 0.912 |
| AHI ≥ 15/h | 3 | 5739 | 0.63 | − 5.45, 6.71 | 82.1 | 0.004 | 0.839 | – | |
| LSpO2 (%) | 4 | 6360 | − 0.10 | − 1.28, 1.09 | 47.2 | 0.128 | Fixed | 0.872 | – |
| ODI (events/hour) | 4 | 6310 | − 0.56 | − 1.68, 0.56 | 30.2 | 0.231 | Fixed | 0.326 | – |
| ArI (events/hour) | 3 | 3074 | − 0.94 | − 2.14, 0.26 | 4.6 | 0.351 | Fixed | 0.123 | – |
| T90 (%) | 3 | 3142 | 0.02 | − 0.42, 0.47 | 0 | 0.536 | Fixed | 0.915 | – |
| ESS score | 4 | 9089 | 0.60 | 0.16, 1.04 | 0 | 0.678 | Fixed | 0.007 | – |
WMD; weighted mean difference, CI; confidence interval, PZ; P value for Z test, PH; P value based on Q test for between-study heterogeneity, AHI; apnea/hypopnea index, LSpO2; lowest peripheral oxygen saturation, ODI; oxygen desaturation index, ArI; arousal index, T90%; percent sleeping time in which oxygen saturation was below 90%, ESS; Epworth Sleepiness Scale