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. 2023 Mar 6;97(3):e00003-23. doi: 10.1128/jvi.00003-23

FIG 2.

FIG 2

PRV infection induces IL-1β and IL-18 expression and secretion in mice. (A) Survival rate of WT mice (10 mice in the PRV-infected group and 3 mice in the PBS-infected group). (B to E) Detection of proinflammation cytokines (IL-1β, IL-6, IL-18, and TNF-α) in serum by ELISA. (F to I) Detection of the mRNA levels of proinflammation cytokines (IL-1β, IL-6, IL-18, and TNF-α) in the spleen, lung, and brain by qPCR. (J, K) Detection of PRV DNA copy number in blood, spleen, lung, and brain. The results shown are representative of three independent experiments (n = 3 mice per group). *, P < 0.05; **, 0.001 < P < 0.01; ***, P < 0.001. All error bars show standard deviations (SDs).