FIG 8.

AIM2 inflammasome is critical for host defense against PRV infection in mice. (A) Survival rates of WT, Nlrp3^−/−, and Aim2^−/− mice infected with PRV at 20 PFU/each mouse by tail vein injection (n = 10 per group). Statistical significance was determined by the log-rank test. (B to H) The WT and Nlrp3^−/−- and Aim2^−/−-deficient mice were infected with PRV at 20 PFU/each mouse by tail vein injection for 24 h. The levels of IL-1β (B), IL-6 (C), and TNF-α (D) in serum were detected by ELISA. The mRNA levels of IL-1β (E) and the PRV DNA copy number (F) in the tissues were analyzed with qPCR. (G, H) Pathological lesions of mice (H&E staining) from the lung were shown. Data are representative of three independent experiments with three biological replicates (mean ± SD in panels B to F) (two-way ANOVA in panels B to F). *, P < 0.05; **, 0.001 < P < 0.01; ***, P < 0.001; ns, no significance.