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IFNs and proinflammatory cytokines were elevated in SADS-CoV-infected mice. Seven-day-old BALB/c mice were inoculated i.c. with SADS-CoV or cell culture medium and were euthanized at 3 dpi. The brain, lung, intestine, and spleen were collected and analyzed for the expression of CXCL10 (A), IL-1β (B), IL-6 (C), IL-8 (D), TNF-α (E), GM-CSF (F), IFN-β (G), IFN-γ (H), and IFN-λ3 (I) by real-time PCR analysis. *, P < 0.05; **, P< 0.01, relative to the mock group.
