TABLE 1.

Percent amino acid identity matrix for 229E (NP_073551.1), NL63 (AFV53148.1), SARS-CoV-2 (QHD43416.1), OC43 (AIX10759.1) and HKU1 (AGW27881.1) full-length spikes and S2 subunits

Protein	229E	NL63	SARS-CoV-2	OC43	HKU1
Full-length spike
229E	100.0
NL63	64.15	100.0
SARS-CoV-2	27.18	26.12	100.0
OC43	27.53	28.57	32.27	100.0
HKU1	28.05	27.06	31.81	65.13	100.0
S2 subunit
229E	100.0
NL63	75.91	100.0
SARS-CoV-2	35.12	34.10	100.0
OC43	33.81	36.51	41.25	100.0
HKU1	34.45	35.56	39.27	73.40	100.0