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. 2023 Mar 16;14:1095034. doi: 10.3389/fimmu.2023.1095034

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Copyright © 2023 Shi, Goo, Kim, Kress, Ogbi, Mintz, Wu, Belin de Chantemèle, Stepp, Long, Guha, Lee, Carbone, Annex, Hui, Kim and Weintraub

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MRL/lpr mice with active disease exhibited partial lipodystrophy. (A) Body weights were monitored weekly. (B) Total weight, fat mass and fat percentage at baseline (7 weeks) and with active disease (14 weeks) measured by NMR. (C-G) Representative images and weights of adipose tissue depots. Subcutaneous (SQAT, (C), gonadal (gAT, (D), retroperitoneal (E), brown (BAT, (F), thoracic aortic PVAT (tPVAT, red arrows, (G) and abdominal aortic PVAT (aPVAT, yellow arrows, (G) and mesenteric arterial PVAT (mPVAT, yellow arrows, (H). In all images, MRL tissues are depicted on the left and MRL/lpr on the right. n=10-15. ****p<0.0001 vs MRL (control). ns, not significant.