Figure 3.

MRL/lpr mice with active disease displayed normal blood pressure and metabolic health. Systolic blood pressure (A) was measured using tail cuff (n=8). Fasting blood glucose (B) and insulin (C) levels were measured, and estimated insulin sensitivity as insulin resistance index (HOMA-IR) (D) was calculated using the University of Oxford HOMA calculator software (n=15). Glucose tolerance tests (GTT, (E) were performed and the area under the curve (AUC, (F) between MRL/lpr and MRL was compared (n=5). (G) and (H) representative plasma lipoprotein profiles measured via FPLC using pooled plasma (0.22 ml) from 4 MRL/lpr mice and 5 MRL mice. Plasma levels of triglyceride (I) and cholesterol (J) were also measured using biochemical assays (n=10). VLDL, very low-density lipoprotein; IDL, intermediate-density lipoprotein; LDL, low-density lipoprotein; HDL, high-density lipoprotein. ns, not significant.