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. 2023 Mar 7;14:1087081. doi: 10.3389/fpsyg.2023.1087081

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Copyright © 2023 Marcu, Szekely-Copîndean, Radu, Bucuță, Fleacă, Tănăsescu, Roman, Boicean and Băcilă.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Topographical distribution of alpha average power percent difference between major depression group non-treatment-resistant (non-TRD) and treatment-resistant depression group (TRD), showing a 34% difference for the alpha band (8–120 Hz) at P4 site and a maximum difference at 9 Hz: 50% bigger at P4 in the non-TRD group. (B) Difference in FFT amplitude asymmetry across all sites between non-TRD and TRD group, showing a slight significant value (p < 0,05) at P3-P4 sites in conventional alpha band (bottom). The thin blue line linking P3 and P4 sites is interpreted as smaller alpha asymmetry at the parietal site, for the non-TRD group.