Table II.
Among infants hospitalized for bronchiolitis with severe wheezing phenotype, unadjusted and adjusted models for asthma development by age 6 years (n = 162)
| Characteristics at enrollment | Unadjusted |
Adjusted |
||
|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | |
| Age at enrollment | ||||
| <2 mo | 0.65 (0.41-1.04) | .07 | 0.70 (0.43-1.12) | .14 |
| ≥2 mo | 1.00 (ref) | — | 1.00 (ref) | — |
| Sex | ||||
| Female | 1.00 (ref) | — | 1.00 (ref) | — |
| Male | 1.30 (0.71-2.41) | .40 | 0.98 (0.48-2.00) | .95 |
| Race/ethnicity | ||||
| Non-Hispanic White | 1.00 (ref) | — | 1.00 (ref) | — |
| Non-Hispanic Black | 2.04 (1.00-4.16) | .05 | 1.41 (0.71-2.82) | .33 |
| Hispanic | 1.74 (0.83-3.65) | .14 | 1.31 (0.64-2.71) | .46 |
| Preterm birth (32 to 37 wk) | 2.15 (1.36-3.38) | .001 | 2.38 (1.43-3.96) | .001 |
| Child history of eczema | 3.00 (1.41-6.34) | .004 | 2.62 (1.13-6.09) | .03 |
| Ever attended day care | 0.74 (0.46-1.20) | .22 | 0.68 (0.42-1.08) | .10 |
| Maternal history of asthma | 2.37 (1.34-4.17) | .003 | 1.92 (1.01-3.64) | .05 |
| Intensive care unit admission | 1.47 (0.77-2.82) | .24 | 1.44 (0.64-3.21) | .38 |
| Result of testing for respiratory syncytial virus | ||||
| Positive | 0.34 (0.15-0.74) | .006 | 0.44 (0.22-0.89) | .02 |
| Negative | 1.00 (ref) | — | 1.00 (ref) | — |
| Result of testing for rhinovirus | ||||
| Positive | 2.14 (0.85-5.40) | .11 | 2.12 (0.92-4.89) | .08 |
| Negative | 1.00 (ref) | — | 1.00 (ref) | — |
| Specific IgE to aeroallergen or food∗ | ||||
| Yes | 1.65 (0.77-3.53) | .20 | — | — |
| No | 1.00 (ref) | — | — | — |
| Blood eosinophil concentration | ||||
| <4% | 1.00 (ref) | — | — | — |
| ≥4% | 1.59 (0.57-4.40) | .38 | — | — |
All results were adjusted for potential clustering by index hospital. Boldface indicates statistically significant results.
OR, Odds ratio; ref, reference.
Serum sIgE to food or aeroallergen measured at the Phadia Immunology Reference Laboratory (Portage, Mich). Any test result that was positive for specific IgE to at least 1 of 5 foods (milk, egg, peanut, cashew, or walnut) defined as at least 0.35 kU/L or specific IgE to any of 112 components on the ImmunoCAP Immuno-solid-phase Allergen Chip from 51 allergen sources (foods, molds, trees, dust mite, cockroach, dog, etc) defined as at least 0.30 Immuno-solid-phase Allergen Chip (ISAC) standardized units (ISU-E).