Fig 7. Comparison between changes over time in sequence abundance of selected V5 and V6 regions present in the inoculum treponemes and the development of humoral immunity to the same regions, assessed by ELISA performed with sera from infected rabbits and synthetic peptides.
Panels A-C (sequence abundance) and D-F (humoral response to the selected peptide) pertain to rabbits infected with the WT strain, while panels G-I (sequence abundance) and J-L (humoral response to the selected peptide) pertain to rabbits infected with the SS14-DCKO strain. Sequence abundance was based on the tprK deep sequencing results for all rabbits.