TABLE 2.
Tumor Response After PDT Light Applications
| Patient # | Diagnosis | Tumor Size (cm) | PDT Light Applications (Day 3) | Tumor Response | Days From PDT to Surgery | Tumor Cell Necrosis (%) | Brisk Inflammatory Reaction |
|---|---|---|---|---|---|---|---|
| Nonresection study | |||||||
| 1 | Squamous cell carcinoma | 2.8 | 1 | 3 mo: SD 6 mo: PD | — | — | — |
| 2 | Carcinoid | 1.6 | 1 | 3 mo: SD 6 mo: SD | — | — | — |
| 3 | Adenocarcinoma metastasis from colon | 1.5 | 3 | 3 mo: SD 6 mo: SD | — | — | — |
| 4 | Squamous cell carcinoma | 1.1 | 2, 2*;2*, 1* | 3 mo: CR 6 mo: CR | — | — | — |
| 5 | Adenocarcinoma | 1.3 | 1 | 3 mo: SD 6 mo: SD | — | — | — |
| Resection study | |||||||
| 1 | Adenocarcinoma | 3.00 | 1 | No | 12 | 20 | Yes |
| 2 | Squamous cell | 1.30 | 1 | No | 13 | 40 | Yes |
| 3 | Adenocarcinoma | 2.60 | 1 | No | 14 | 40 | Yes |
| 4 | Adenocarcinoma | 2.77 | 3 | No | 15 | 35 | Yes |
| 5 | Squamous cell | 1.80 | 1 | Yes† | 32 | No residual tumor | Not applicable |
| 6 | Adenocarcinoma | 3.30 | 2 | No | 15 | 10 | Yes |
| 7 | Adenocarcinoma | 2.10 | 3 | No | 12 | 5 | Yes |
| 8 | Adenocarcinoma | 1.70 | 2 | No | 12 | 10 | Yes |
| 9 | Adenocarcinoma | 2.10 | 1 | No | 13 | 50 | Yes |
| 10 | Adenocarcinoma | 2.10 | 4‡ | No | 18 | 10 | Yes |
*
PDT applications after first porfimer sodium injection: 2 on day 3, 2 on day 5; after second porfimer sodium injection: 2 on day 3, 2 on day 6.
†
No nonviable/necrotic tumor at resection.
‡
4 placements for total dose of 200 J.
—indicates not evaluated, no tumor resection in this study; PDT, photodynamic therapy.