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. 2023 Feb 21;147(14):1097–1109. doi: 10.1161/CIRCULATIONAHA.122.062349

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© 2023 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 1. — Manhattan plot for the genome-wide association analysis of primary aldosteronism. Manhattan plots showing −log₁₀(P value) of the genome-wide association study of primary aldosteronism (PA) in the Japanese cohort (A) and meta-analysis (B). The red horizontal line indicates the genome-wide significance threshold (P=5.0×10⁻⁸). We also display a suggestive significance threshold (P=1.0×10⁻⁶) as the blue horizontal line in the Japanese genome-wide association study.