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. 2023 Mar 17;14:1140703. doi: 10.3389/fphar.2023.1140703

FIGURE 4.

FIGURE 4

FX1 protects chronic cardiac transplant rejection in mice (A). Illustration of the experimental design in (B–E). The murine chronic cardiac transplant model was established, and the mice were treated with FX1 or the equivalent amount of PBS three times. The survival time of the cardiac grafts was observed, and the spleens were collected for FCM analysis on the 28th postoperative day (B). The survival status of the grafts was observed every day through palpation, and the survival time is illustrated in the survival curves (n = 6) (C). Graft specimens were obtained on the 28th postoperative day, and vascular occlusion and fibrosis in the cardiac grafts was assessed by H&E, elastica van Gieson, and Masson staining (D). The bar charts shows the vascular occlusion and fibrosis of the cardiac grafts (n = 6). Error bars represent SD. ns, not significant, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.