Table 1.
The Extent of Pleiotropy as Defined With Different Annotation Methods
| Definition | Pleiotropic | Immune Non-pleiotropic | Dev Non-pleiotropic | |
|---|---|---|---|---|
| 1 | Immune = all Immune GO + previous citations. + DE (808) | 354 (43.8%) dN/dS = 0.062 | 454 dN/dS = 0.085 | 2992 dN/dS = 0.063 |
| Dev = all Dev GO | ||||
| 2 | Immune = Immune Response GO + previous citations + DE (753) | 299 (39.7%) dN/dS = 0.063 | 454 dN/dS = 0.085 | 3047 dN/dS = 0.063 |
| Dev = all Dev GO | ||||
| 3 | Immune = Immune Response GO + previous citations + DE (753) | 52 (6.9%) dN/dS = 0.051 | 701 dN/dS = 0.077 | 210 dN/dS = 0.056 |
Note.—GO, Gene Ontology annotation terms; DE, differentially expressed via transcriptional analyses; Dev, developmental; Previous citations, genes or gene lists manually or computationally identified as having immune system functions in Drosophila. dN/dS, median dN/dS value of that class.