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. 2023 Feb 27;12:e80942. doi: 10.7554/eLife.80942

Table 7. In Swiss-Prot, there are 16 candidate domain architectures available for our Enzyme Commission (EC) functional localisation experiment.

Among these, all domain architectures with more than three instances in Swiss-Prot (seven of them) are 100% correctly ordered by our class activation mapping (CAM) method.

Domain architecture diversity in bifunctional enzymes.

First domain Second domain Number ordered correctly Number times seen Percent correct
EC:2.7.7.60 EC:4.6.1.12 94 94 100
EC:4.1.99.12 EC:3.5.4.25 83 83 100
EC:3.5.4.19 EC:3.6.1.31 59 59 100
EC:1.8.4.11 EC:1.8.4.12 20 20 100
EC:4.1.1.48 EC:5.3.1.24 18 18 100
EC:5.4.99.5 EC:4.2.1.51 12 12 100
EC:5.4.99.5 EC:1.3.1.12 4 4 100
EC:4.2.1.10 EC:1.1.1.25 3 3 100
EC:2.7.7.61 EC:2.4.2.52 0 3 0
EC:2.7.1.71 EC:4.2.3.4 0 2 0
EC:1.1.1.25 EC:4.2.1.10 0 1 0
EC:2.7.2.3 EC:5.3.1.1 1 1 100
EC:4.1.1.97 EC:1.7.3.3 1 1 100
EC:4.1.3.1 EC:2.3.3.9 1 1 100
EC:5.1.99.6 EC:1.4.3.5 0 1 0
EC:1.8.4.12 EC:1.8.4.11 0 1 0