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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: Nat Immunol. 2023 Jan 19;24(2):309–319. doi: 10.1038/s41590-022-01395-9

Extended Data Fig. 4. Clonal expansion of CD4+ and CD8+ T cells across sites.

Extended Data Fig. 4

Combined frequency of top 100 clones among CD4+ and CD8+ T cells from nine tissue sites. The height of each bar represents mean frequencies averaged across four donors. Statistical significance was calculated using two-way ANOVA matching tissue and CD4+/CD8+ subset and comparing each subset with the other subset in that tissue, followed by Tukey’s multiple comparisons test and indicated by ****, p ≤ 0.0001; ***, p ≤ 0.001; *, p ≤ 0.05. Error bars represent standard deviation. (n=4 independent human donors from each site). For raw data and individual p-values, see source data.