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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: Nat Immunol. 2023 Jan 19;24(2):309–319. doi: 10.1038/s41590-022-01395-9

Extended Data Fig. 8. Transcriptional heterogeneity of skin TRM.

Extended Data Fig. 8

(a) UMAP embedding of skin TRM colored by Leiden cluster (top left), or gene expression. Color intensity of individual cells is based on scaled log (normalized count per ten thousand (CP10k)+1) of the indicated markers. (b) Heatmap depicting average expression of genes associated with T cell function upregulated (p-value < 0.05, log-fold change > 0.3) in each Leiden cluster. Intensity represents the mean column-normalized expression for the indicated gene. Statistical significance was calculated using a two-sided Wilcoxon with tie correction, followed by a Benjamini-Hochberg adjustment for multiple comparisons. (c) UMAP embeddings of skin TRM colored by expression of differentially expressed genes, as in (a).