Fig. 8.

In vivo P10G20 antioxidation and antifibrosis tests. a,b,c,d) The content of H₂O₂ in uterine tissue on day 0.5 (a), day 1 (b), day 3 (c), and day 7 (d) post-surgery. (n = 3, mean ± SD, ns: not significant, *p < 0.05, **p < 0.01, ****p < 0.0001) e,f) Relative mRNA level of TGF-β1 in rat uteri on day 1 (e) and day 3 (f). (n = 3, mean ± SD, *p < 0.05, **p < 0.01, ****p < 0.0001) g,h) Relative mRNA level of VEGF in rat uteri on day 1 (g) and day 3 (h). (n = 3, mean ± SD, ns: not significant, **p < 0.01, ****p < 0.0001) i) Scheme showing that the antioxidant properties of P10G20 slowed down the occurrence of oxidative stress in tissue, which downregulated the levels of TGF-β1 and VEGF. The decreased fibrosis-related cytokines reduced the deposition of the ECM, which inhibited IUA development. Statistical significance was calculated with ANOVA with a Tukey post-hoc test in a, b, c, d, e, f, g, and h.