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. 1975 Feb;34(1):26–37. doi: 10.1136/ard.34.1.26

Development with age of human articular cartilage surface structure. A survey by interference microscopy of the lateral femoral condyle.

R B Longmore, D L Gardner
PMCID: PMC1006341  PMID: 1124953

Abstract

The weight-bearing surfaces of the lateral femoral condyles taken from twenty normal human cadavers aged 0-47 years have been examined by reflected light interference microscopy (RLIM) and by scanning electron microscope (SEM). The surfaces appeared normal by naked eye examination. The presence of both 200-400 mum diameter secondary undulations and small ovoid 20-45 mum diameter tertiary hollows was confirmed in all specimens using both techniques. Measurements by RLIM showed that the tertiary hollows increase significantly in depth and diameter with increasing age. A further order of quaternary surface irregularities was shown. Small irregular ridges, 130-275 nm deep and 1-4 mum diameter, were found with increasing frequency on specimens obtained from persons aged 21 years. These quaternary irregularities are thought to be due to exposure of superficial fibre bundles after the loss, with age, of surface ground substance.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bullough P., Goodfellow J. The significance of the fine structure of articular cartilage. J Bone Joint Surg Br. 1968 Nov;50(4):852–857. [PubMed] [Google Scholar]
  2. Byers P. D., Contepomi C. A., Farkas T. A. A post mortem study of the hip joint. Including the prevalence of the features of the right side. Ann Rheum Dis. 1970 Jan;29(1):15–31. doi: 10.1136/ard.29.1.15. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. COLLINS D. H., MEACHIM G. Sulphate (35SO4) fixation by human articular cartilage compared in the knee and shoulder joints. Ann Rheum Dis. 1961 Jun;20:117–122. doi: 10.1136/ard.20.2.117. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Gardner D. L. The influence of microscopic technology on knowledge of cartilage surface structure. Ann Rheum Dis. 1972 Jul;31(4):235–258. doi: 10.1136/ard.31.4.235. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gardner D. L., Woodward D. Scanning electron microscopy and replica studies of articular surfaces of guinea-pig synovial joints. Ann Rheum Dis. 1969 Jul;28(4):379–391. doi: 10.1136/ard.28.4.379. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Inoue H., Kodama T., Fujita T. Scanning electron microscopy of normal and rheumatoid articular cartilages. Arch Histol Jpn. 1969 Aug;30(5):425–435. doi: 10.1679/aohc1950.30.425. [DOI] [PubMed] [Google Scholar]
  7. Kempson G. E., Freeman M. A., Swanson S. A. Tensile properties of articular cartilage. Nature. 1968 Dec 14;220(5172):1127–1128. doi: 10.1038/2201127b0. [DOI] [PubMed] [Google Scholar]
  8. Longfield M. D., Dowson D., Walker P. S., Wright V. "Boosted lubrication" of human joints by fluid enrichment and entrapment. Biomed Eng. 1969 Nov;4(11):517–522. [PubMed] [Google Scholar]
  9. McCall J. G. Scanning electron microscopy of articular surfaces. Lancet. 1968 Nov 30;2(7579):1194–1194. doi: 10.1016/s0140-6736(68)91680-2. [DOI] [PubMed] [Google Scholar]
  10. McDevitt C. A. Biochemistry of articular cartilage. Nature of proteoglycans and collagen of articular cartilage and their role in ageing and in osteoarthrosis. Ann Rheum Dis. 1973 Jul;32(4):364–378. doi: 10.1136/ard.32.4.364. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Meachim G., Sheffield S. R. Surface ultrastructure of mature adult human articular cartilage. J Bone Joint Surg Br. 1969 Aug;51(3):529–539. [PubMed] [Google Scholar]
  12. Stockwell R. A. The cell density of human articular and costal cartilage. J Anat. 1967 Sep;101(Pt 4):753–763. [PMC free article] [PubMed] [Google Scholar]
  13. Walker P. S., Dowson D., Longfield M. D., Wright V. "Boosted lubrication" in synovial joints by fluid entrapment and enrichment. Ann Rheum Dis. 1968 Nov;27(6):512–520. doi: 10.1136/ard.27.6.512. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Weightman B. O., Freeman M. A., Swanson S. A. Fatigue of articular cartilage. Nature. 1973 Aug 3;244(5414):303–304. doi: 10.1038/244303a0. [DOI] [PubMed] [Google Scholar]
  15. Wilkins J. Proteolytic destruction of synovial boundary lubrication. Nature. 1968 Sep 7;219(5158):1050–1051. doi: 10.1038/2191050a0. [DOI] [PubMed] [Google Scholar]

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