Table 2.

Inhibition specificity of N-TIMP2 variants.

N-TIMP2 variant	Inhibition specificity ratioa
	MMP-2CAT	MMP-9CAT
N-TIMP2	3.05	2.21
N-TIMP2-S2DOPA	4.66	23.51
N-TIMP2-S69DOPA	46.61	45.85
N-TIMP2-A70DOPA	13.49	23.43
N-TIMP2-L100DOPA	14.17	16.73
N-TIMP2-S2HqAla	1.00	1.39
N-TIMP2-Y36HqAla	11.43	8.69
N-TIMP2-S69HqAla	18.96	25.59
N-TIMP2-A70HqAla	1.63	14.11

^aSpecificity is calculated as the ratio between the affinity (K_i) for MMP-14_CAT in comparison with other MMPs [K_i for MMP-14_CAT/K_i for MMP-2_ACT or MMP-9_CAT].