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. 2023 Mar 30;14:1775. doi: 10.1038/s41467-023-37327-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a, b Tomographic slices show the apical tip of a N. caninum cell with the secretory organelles organized around the ICMT (green) inside the protruded conoid complex in longitudinal views (a, a’—protruded original and pseudo-colored; b—retracted). The long ICMTs connect the apex of the conoid to the cytosol, and are closely co-localized with the secretory vesicles (light blue) and two rhoptries (rose). Note that the membrane-associated, most-apical vesicle is not visible in the tomographic slice shown in (a), but is visible in panels (c, d) and Fig. 7b. Other coloring: CFs (orange), micronemes (dark blue), sheet-like density (gold), inter-vesicular connections (pink), “crowning” density that caps the apical minus-end of the ICMT (purple). c–e 3D segmentation and visualization of tomograms shown in (a and b, respectively), i.e., with protruded (c, d) and retracted (e) conoid, showing the overall organization of secretory organelles within the conoid complex, including CFs (trimmed from the front to show the content inside), micronemes, rhoptries, ICMT, vesicles, inter-vesicular connections, sheet-like structure along micronemes, and plasma membrane (gray). d shows a zoom-in from (c), with conoid fibers hidden for clarity. f, g Cross-sectional slices through the protruded (f, f’—original and pseudo-colored) and retracted (g) conoids from the tomograms shown in (a and b). Scale bars: 100 nm (in a, b); 50 nm (in f, g).