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. 2023 Mar 30;3:46. doi: 10.1038/s43856-023-00273-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Unsupervised hierarchical clustering of tumors in the discovery cohort (n = 100) identified two phenotypes of early changes in intratumor heterogeneity: decreasing heterogeneity from T1 to T2 (Phenotype 1, in blue) and increasing heterogeneity from T1 to T2 (Phenotype 2, in red). b Kaplan-Meier curves for recurrence free survival (RFS) of patient groups split by phenotype show significant separation, with tumors showing increase in intratumor heterogeneity after initiation of neoadjuvant therapy (Phenotype 2) having worse recurrence outcomes.