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. 2023 Jan 19;5(1):43–51. doi: 10.1007/s44228-022-00023-5

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© Genentech, Inc. 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Mean (±SD) RO7297089 serum concentration–time profiles following the first dose in patients administered a flat dose (Cohorts 1-4A) 60–1080 mg or a split dose (Cohorts 4B & 5B) 1080 and 1850 mg QW. Dashed line at the bottom indicates the lower limit of quantitation. PK data from 6 patients were excluded from the plot due to not receiving the full dose, missed sample, and an obvious outlier with C_trough concentration higher than concentration at the end of infusion