Table 1.
Cohort details for Mendelian Randomization (MR) analyses.
| Trait | Population cohort | Mean Age | % Female | Sample size | Cases | Controls | PMID |
|---|---|---|---|---|---|---|---|
| Fasting Insulin (FI) | MAGIC | 50.7 | 51.2 | 151,013 | Not applicable | Not applicable | 34059833 |
| Type 2 Diabetes (T2D) | DIAGRAM/GERA/UK Biobank | 54.1/63.3/56.9* | 50.1/59.0/54.2* | 655,666 | 61,714 | 593,952 | 30054458 |
| Fasting Glucose (FG) | MAGIC | 50.9 | 47.7 | 133,010 | Not applicable | Not applicable | 22885924 |
| Hemoglobin (Hb) | UK Biobank | 56.7 | 54.9 | 563,946 | Not applicable | Not applicable | 32888493 |
| Red Cell Count (RCC) | UK Biobank | 56.7 | 54.9 | 545,203 | Not applicable | Not applicable | 32888493 |
| Reticulocytes (RETIC) *** | UK Biobank | 56.7 | 54.9 | 408,112 | Not applicable | Not applicable | 32888494 |
| HbA1c** | MAGIC | 52.3 | 57.9 | 146,806 | Not applicable | Not applicable | 34059833 |
| HbA1c**/*** | UK Biobank | 56.7 | 54.9 | 389,889 | Not applicable | Not applicable | 34017140 |
*Study-specific characteristics were not available for all UK Biobank data and was extrapolated from data available.
a
Output from MRC IEU GWAS pipeline analysis using Phesant derived variables from UK Biobank, version 2: https://doi.org/10.5523/bris.pnoat8cxo0u52p6ynfaekeigi.
**To minimize overlap, bidirectional MR analyses with FI was undertaken with HbA1c measure in the UK Biobank, but for WHR adjusted for BMI analyses HbA1c was assessed in MAGIC.
***Estimated from available UK Biobank data (PMID 32888493) as data not available.