. 2023 Mar 17;14:1146099. doi: 10.3389/fendo.2023.1146099

Table 3.

Univariable MR analyses of fasting insulin (FI) as exposure and hemoglobin (Hb), red cell count (RCC) and reticulocyte count (RETIC) as outcomes.

Method	β	Standard Error	P	Egger-Intercept	p_Egger	Cochrane’s Q	Q df	p_Q	I²	F
Univariable MR Analysis — Exposure: FI (49 SNPs, single nucleotide polymorphisms), Outcome: Hb
MR Egger	0.678	0.231	0.005	-0.002	0.534	857.625	47	1.95x10^-149	94.520	19.221
Weighted median	0.506	0.047	6.22x10^-27							19.221
Inverse variance weighted	0.544	0.086	2.70x10 ^-10			864.803	48	2.80x10^-150	94.450	19.221
Simple mode	0.624	0.090	9.43x10^-9							19.221
Weighted mode	0.575	0.063	4.54x10^-12							19.221
Univariable MR Analysis — Exposure: FI (49 SNPs), Outcome: RCC
MR Egger	1.070	0.307	0.001	-0.009	0.068	1520.582	47	8.23x10^-288	96.909	19.221
Weighted median	0.377	0.055	7.66x10^-12							19.221
Inverse variance weighted	0.539	0.118	5.38x10^-6			1633.210	48	0	97.061	19.221
Simple mode	0.401	0.134	0.004							19.221
Weighted mode	0.443	0.098	3.85x10^-5							19.221
Univariable MR Analysis — Exposure: FI (49 SNPs), Outcome: RETIC
MR Egger	-0.026	0.379	0.946	0.012	0.045	1744.044	47	0	97.305	19.221
Weighted median	0.605	0.061	6.49x10^-23							19.221
Inverse variance weighted	0.698	0.147	2.18x10^-6			1902.129	48	0	97.477	19.221
Simple mode	0.819	0.116	6.18x10^-9							19.221
Weighted mode	0.684	0.076	7.48x10^-12							19.221