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. 2023 Feb 13;3(3):100287. doi: 10.1016/j.xops.2023.100287

Figure 2.

Figure 2

Cohort details. The primary study cohort included all European UK Biobank (UKBB) participants. Within this cohort, glaucoma was defined by a combination of self-reported and International Classification of Diseases, Tenth Revision (ICD10) "glaucoma diagnosis." Deceased participants were included in analyses with age determined from "age at death." The first replication cohort included all European individuals from the Canadian Longitudinal Study of Aging (CLSA). Within this cohort, glaucoma was defined by self-reported diagnosis at the time of recruitment. The second replication cohort pooled primary open-angle glaucoma (POAG) cases from the Australian and New Zealand Registry of Advanced Glaucoma (ANZRAG) and nonglaucoma controls from the Blue Mountains Eye Study (BMES). ∗Participants with rare apolipoprotein E genotypes including E1E2 (n = 2) and E1E4 (n = 17) were excluded from the final sample.