Table 2. Pooled HRs for high expression of HOTAIR with respect to OS in different subgroups of patients.

Stratified analysis	Studies, n	Patients, n	Pooled HR (95% CI)	P-value	Heterogeneity
					I2, %	P-value	Model
Tumor type
Esophageal cancer	6	544	1.94 (1.35, 2.52)	<0.001	0.00	0.856	Fixed effect
Gastric cancer	14	1492	1.58 (1.35, 1.81)	<0.001	0.00	0.781	Fixed effect
Colorectal cancer	7	580	1.46 (0.99, 1.93)	<0.001	0.00	0.683	Fixed effect
Hepatocellular carcinoma	1	64	3.26 (−0.04, 6.56)	0.053	-	-	Fixed effect
Pancreatic cancer	1	78	1.06 (0.45, 1.66)	0.001	-	-	Fixed effect
Cholangiocarcinoma	1	33	1.89 (0.67, 3.11)	0.002	-	-	Fixed effect
Country
China	22	2119	1.53 (1.35, 1.72)	<0.001	0.00	0.743	Fixed effect
Japan	4	382	2.15 (1.16, 3.14)	<0.001	0.00	0.934	Fixed effect
Denmark	1	40	3.40 (−0.80, 7.60)	0.113	-	-	Fixed effect
Lithuania	1	127	3.13 (−0.69, 6.95)	0.108	-	-	Fixed effect
Czech	1	73	4.46 (−5.68, 15.60)	0.361	-	-	Fixed effect
Sample size
≥100	10	1187	1.58 (1.34, 1.82)	<0.001	0.00	0.823	Fixed effect
<100	20	1554	1.54 (1.25, 1.83)	<0.001	0.00	0.699	Fixed effect
Analysis type
Multivariate analysis	17	1907	1.56 (1.35, 1.76)	<0.001	0.00	0.864	Fixed effect
Other	13	834	1.60 (1.17, 2.03)	<0.001	0.00	0.557	Fixed effect

Abbreviations: CI, confidence interval; HR, hazard ratio.