Table 2.
Main clinical data and laboratory tests associated with DNR in elderly patients who underwent a major thoracic surgery
| Item | DNR(n = 26) | Non-DNR(n = 128) | P value |
|---|---|---|---|
| Preoperative blood tests | |||
| Hemoglobin < 110 | 1(3.85%) | 8(6.25%) | 1.000 |
| Creatinine clearance (ml/min) | 63.50(59.35–72.85) | 65.10(56.98–78.08) | 0.54 |
| Pre-WBC levels (× 109 /L) | 4.35(3.84–5.11) | 5.96(4.92–7.06) | 0.02* |
| Post-WBC levels (×109 /L) | 12.47(9.89-17.00) | 14.07(11.69–16.66) | 0.243 |
| WBC gap | 7.73(5.37–11.40) | 7.92(5.45–10.52) | 0.887 |
| NLR | 1.98(1.41–2.38) | 2.00(1.44–2.61) | 0.771 |
| Hb levels | 135.00(127.50-141.50) | 132(125–139) | 0.259 |
| Albumin (g/L) | 40.3(38.80–43.40) | 40.70(38.30–43.20) | 0.871 |
| CRP ≥ 5 | 2(7.69%) | 13(10.16%) | 0.981 |
| Surgical data | |||
| Perioperative inadvertent hypothermia(<35℃) | 8(30.77%) | 16(12.5%) | 0.041* |
| Blood loss | 0.659 | ||
| <200 | 23(88.46%) | 117(91.41%) | |
| 200–500 | 2(7.69%) | 9(7.03%) | |
| >500 | 1(3.85%) | 2(1.56%) | |
| Hypotension(MAP < 65mmHg) | 6(23.08%) | 32(25.00%) | 0.836 |
| VICA(use sevoflurane ≥ 50 min) | 5(19.23%) | 12(9.38%) | 0.144 |
| Midazolam as a pre-anaesthetic sedative | 16(61.54%) | 94(73.44%) | 0.221 |
| Dexmedetomidine | 21(80.77%) | 113(88.28%) | 0.472 |
| Rescue analgesia | |||
| Opium analgesic | 10(38.46%) | 56(43.75%) | 0.619 |
| Ketorolac Tromethamine | 17(65.38%) | 86(67.19%) | 0.859 |
| NRS | |||
| 1st day after operation(resting) | 0.792 | ||
| <4 | 22(84.62%) | 111(86.72%) | |
| 4–6 | 4(15.38%) | 16(12.50%) | |
| >6 | 0 | 1(0.78%) | |
| 1st day after operation(activity) | |||
| <4 | 14(53.85%) | 72(56.25%) | 0.730 |
| 4–6 | 12(46.15%) | 51(39.84%) | |
| >6 | 0 | 5(3.91%) | |
| 1st day after operation(coughing) | 0.364 | ||
| <4 | 9(34.62%) | 57(44.53%) | |
| 4–6 | 16(61.54%) | 69(53.91%) | |
| >6 | 1(3.85%) | 2(1.56%) | |
| Chest tube duration ≥ 4 days | 10(38.46%) | 68(53.13%) | 0.173 |
| Postoperative hospital stay(days) | 7(6–9) | 7(6–8) | 0.723 |
| Postoperative body temperature > 38 ℃ | 4(15.38%) | 38(29.69%) | 0.135 |
Abbreviations: DNR Delayed Neurocognitive Recovery, NRS Numeric Rating Scales, NLR Neutrophil-to-lymphocyte Ratio, VICA Intravenous inhalation combined anesthesia
Continuous variables are presented as median [IQR] or mean ± SD, and categorical variables as count (%).
*P < 0.05.