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. 2023 Mar 17;14:1098700. doi: 10.3389/fimmu.2023.1098700

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Copyright © 2023 Yang, Wei, Cheng, Ding, Li, Wang, Yang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interaction of BTG2 and SerpinB5 with cisplatin. (A, D) The binding mode of cisplatin to BTG2 and SerpinB5 in the active site. (B, E) Stereoview of binding mode for cisplatin with BTG2 and SerpinB5 in the binding site. (C, F) The detailed view of the 2-D ligand interaction among cisplatin with BTG2 and SerpinB5. The mRNA expression level in normal lung tissue is expressed by “+”. “++” respect the mRNA expression level was increased in LUAD tissue, “-” respect the mRNA expression level was decreased in LUAD tissue. Compared with tumor group,there was more “+” when the mRNA level increased after treated with cisplatin.