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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Biomaterials. 2022 Apr 28;285:121536. doi: 10.1016/j.biomaterials.2022.121536

Fig. 2. DIPMA nanoparticles, non-evoked behavior in neuropathic pain.

Fig. 2.

Non-evoked nociceptive behavior in SNI and sham control mice recorded for 30 min at 90 min after intrathecal injection of DIPMA-AP, AP (500 nM AP), DIPMA-Ø or gabapentin (1000 nM). Distance from wall (A), grooming (B), ambulation (C), track length (D), average velocity, (E) and locomotor activity (F) were recorded. G-L are records of tracks of mice. M shows crossing events in area marked by black square. Mean ± SEM, N = 10 mice. *, +, #P < 0.05; **, ++, ##P < 0.01; ***, +++, ###P < 0.005; ****, ++++, ####P < 0.001. * Sham to all others groups; + gabapentin to sham, SNI and DIPMA-Ø; # DIPMA-AP to sham, SNI, DIPMA-Ø and AP. Two-way ANOVA, Tukey’s multiple comparisons test.