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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Biomaterials. 2022 Apr 28;285:121536. doi: 10.1016/j.biomaterials.2022.121536

Fig. 7. Nanostars, mechanical and cold allodynia in neuropathic pain.

Fig. 7.

A. Effects of VBA-AP, Benzo-AP or AP (1000 nM AP), VBA-Ø or Benzo-Ø on VFF withdrawal responses (mechanical allodynia) of contralateral paw. B, C. Effects of VBA-AP, Benzo-AP, PFPA-AP, AP (1000 nM AP), VBA-Ø, Benzo-Ø or PFPA-Ø on VFF withdrawal responses of ipsilateral paw. B shows time course and C shows AUC. D. Comparison between AP and AP-NH2 in SNI mice. E,F. Effects of VBA-AP, Benzo-AP, AP (1000 nM AP), VBA-Ø or Benzo-Ø on acetone withdrawal responses (cold allodynia) of ipsilateral paw in SNI mice. E shows time course and F shows AUC. Mean ± SEM, N = 10 mice. *, +, #, $ P < 0.05; **, ++, ##, $ $ P < 0.01; ***, +++, ###, $ $ $ P < 0.005; ****, ++++, ####, $ $ $ $ P < 0.001. * Benzo-AP to AP; + VBA-AP to AP; # Benzo-AP to Benzo-Ø; $ VBA-AP to VBA-Ø. Two-way ANOVA (mechanical and cold allodynia), one-way ANOVA (AUC) with Tukey’s multiple comparison test.