Fig. 8. Nanostars, non-evoked behavior in neuropathic pain.
Non-evoked nociceptive behavior in SNI and sham control mice recorded for 30 min at 90 min after intrathecal injection of VBA-AP, Benzo-AP, AP (1000 nM AP), VBA-Ø or Benzo-Ø. Distance from wall (A), grooming (B), ambulation (C), track length (D), average velocity, (E) and locomotor activity (F) were recorded. G-K are records of tracks of mice. L shows crossing events in area marked by black square. Mean ± SEM, N = 10 mice. *, +, #P < 0.05; **, ++, ##P < 0.01; ***, +++, ###P < 0.005; ****, ++++, ####P < 0.001. * Benzo-AP to Benzo-Ø and, SNI; + Sham to SNI; # VBA-AP to VBA-Ø and SNI. Two-way ANOVA, Tukey’s multiple comparisons test.