Table 3.
The Scores of ASK-12 Items in Patients with Good or Poor Dupilumab Adherence
| ASK-12 Items† | Dupilumab Adherence | p-value | ||
|---|---|---|---|---|
| Good (n = 200) | Poor (n = 83) | |||
| #1. | I just forget to take my medicine some of the time. | 2.0 (1.0–3.0) | 4.0 (2.0–4.0) | <0.0001 |
| #2. | I run out of my medicine because I do not get refills on time. | 1.0 (1.0) | 1.0 (1.0–2.0) | 0.0015 |
| #3. | Taking medicines more than once a day is inconvenient. | 3.0 (1.0–4.0) | 3.0 (2.0–4.0) | 0.0023 |
| #4. | I feel confident that each one of my medicines will help me. | 4.0 (4.0–5.0) | 4.0 (4.0–5.0) | 0.3149 |
| #5. | I know if I am reaching my health goals. | 4.0 (4.0–5.0) | 4.0 (4.0–5.0) | 0.8781 |
| #6. | I have someone whom I can call with questions about my medicines. | 4.0 (3.0–4.3) | 4.0 (4.0) | 0.6104 |
| #7. | My doctor/nurse and I work together to make decisions. | 4.0 (4.0–5.0) | 4.0 (4.0) | 0.4591 |
| #8. | Taken a medicine more or less often than prescribed? | 1.0 (1.0–2.0) | 2.0 (1.0–4.0) | <0.0001 |
| #9. | Skipped or stopped taking a medicine because you did not think it was working? | 1.0 (1.0) | 1.0 (1.0–2.0) | 0.0016 |
| #10. | Skipped or stopped taking medicine because it made you feel bad? | 1.0 (1.0) | 1.0 (1.0) | 0.3538 |
| #11. | Skipped, stopped, not refilled, or taken less medicine because of the cost? | 1.0 (1.0) | 1.0 (1.0) | 0.1569 |
| #12. | Not had medicine with you when it was time to take it? | 1.0 (1.0–2.0) | 1.0 (1.0–2.0) | 0.0618 |
| Total ASK-12 score | 29.0 (26.8–32.0) | 32.0 (30.0–35.5) | <0.0001 | |
Notes: †The Japanese version of ASK-12 was used in this study. All values are described as median (interquartile range). Adapted with permission from Matza LS, Park J, Coyne KS, Skinner EP, Malley KG, Wolever RQ. Derivation and validation of the ASK-12 adherence barrier survey. Ann Pharmacother. 2009;43(10):1621–1630.15
Abbreviation: ASK-12, Adherence Starts with Knowledge-12.