Table 7.
Dose adjustment recommended for gabapentin and pregabalin in kidney failure [66].
|
| ||
|---|---|---|
| DRUG’S NAME | BASED ON CREATINE CLEARANCE (ML/MINUTE) | RECOMMENDED DOSE GIVEN IN THREE DIVIDED DOSES IN ALTERNATE DAYS |
|
| ||
| Gabapentin | 50–79 | 600–180 mg |
|
| ||
| 30–49 | 300–900 mg | |
|
| ||
| 15–29 | 150–600 | |
|
| ||
| <15 | 150–300 | |
|
| ||
| Pregabalin | Based on eGFR, mL/min/1.73 m2 | |
|
| ||
| 30–60 | Initially 75 mg, maximum 300 mg daily | |
|
| ||
| 15–30 | Initially 25–50 mg, maximum 300 mg in two divided doses | |
|
| ||
| <30 | Initially 25 mg once daily and maximum 75 mg once daily | |
|
| ||