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. Author manuscript; available in PMC: 2023 Mar 31.
Published in final edited form as: Anal Chem. 2022 Sep 6;94(37):12604–12613. doi: 10.1021/acs.analchem.2c01034

Figure 3.

Figure 3.

Microscopy image of the PAS-stained section of the healthy nephrectomy post MALDI-MSI. Highlighted within the tissue section are tubular regions identified from MALDI-MSI with differential levels of histone proteoforms, showing higher abundance (ET/yellow) and lower abundance (DT/teal) for an acetylated and dimethylated histone H4 proteoform at m/z 11,306.3939 (−1.12 ppm) and a diacetylated histone H4 proteoform at m/z 11,320.3661 (−1.74 ppm). The bar chart shows extracted mean intensities normalized to the area (mm2), with the calculated ratio for each region averaged below. Error bars represent one standard deviation.