Comparison 8. Dropouts due to adverse effects (tolerability).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
8.1 Antidepressants vs placebo	9	889	Risk Ratio (M‐H, Random, 95% CI)	1.19 [0.54, 2.62]
8.1.1 SSRIs	5	334	Risk Ratio (M‐H, Random, 95% CI)	1.99 [0.71, 5.57]
8.1.2 Tricyclic antidepressants	1	17	Risk Ratio (M‐H, Random, 95% CI)	0.55 [0.04, 7.25]
8.1.3 Other antidepressants	4	538	Risk Ratio (M‐H, Random, 95% CI)	0.59 [0.15, 2.35]
8.2 Antidepressants vs antidepressants	3	237	Risk Ratio (M‐H, Random, 95% CI)	1.04 [0.55, 1.99]
8.2.1 Fluoxetine vs desipramine	1	38	Risk Ratio (M‐H, Random, 95% CI)	1.21 [0.41, 3.62]
8.2.2 Paroxetine vs amitriptyline	1	175	Risk Ratio (M‐H, Random, 95% CI)	0.89 [0.38, 2.08]
8.2.3 Paroxetine vs desipramine	1	24	Risk Ratio (M‐H, Random, 95% CI)	1.69 [0.18, 16.25]