Figure 5. Application of the integrated classifier to patients in the Suspected and Indeterminate groups.

(A) Bar plot showing the number and percentage of patients in the Suspected and Indeterminate groups who were classified as LRTI⁺ by the integrated classifier using a 50% probability threshold. (B) Viruses detected by mNGS and bacteria/fungi identified by the rules-based model (RBM) across the patients classified as LRTI⁺ in the Suspected and Indeterminate groups. HRV, human rhinovirus; RSV, respiratory syncytial virus; PIV, parainfluenza virus; HBoV, human bocavirus; HMPV, human metapneumovirus; HPeV, human parechovirus; IV, influenza virus; HCoV, human coronavirus. (C) Overview of inputs and output of the integrated classifier for all patients in the Suspected and Indeterminate groups. Top bars denote the integrated probability of LRTI and are colored by patient group; black dots represent the input host LRTI probability; bottom vertical bars show the input log₁₀-transformed viral and bacterial scores. Dashed lines indicate the 50% LRTI probability threshold and the 15% rule-out threshold.