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. 2023 Apr 3;133(7):e162324. doi: 10.1172/JCI162324

Figure 8. FOXM1 inhibition diminishes the expression of cell-cycle regulators in vivo.

Figure 8

(A) qRT-PCR analysis of FOXM1 target gene expression in mammary gland samples from MIC/c-Src+/+ mice treated with vehicle or a FOXM1 inhibitor (NB-55) or from untreated MIC/c-SrcL/L mice. FOXM1 target expression was normalized to that of Actb. n = 6 per treatment group. *P < 0.05, **P < 0.01, and ****P < 0.0001, by 1-way ANOVA with Tukey’s post hoc test. (B) Lysates from mammary glands as in A were immunoblotted with the indicated antibodies. Left panel: Representative immunoblot. Right panel: Quantification (fluorescence immunoblotting). Data were normalized to E-cadherin (E-Cad.). n = 4 per genotype. *P < 0.05, **P < 0.01, and ***P < 0.001, by 1-way ANOVA with Tukey’s post hoc test.