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. 2023 Apr 3;133(7):e160016. doi: 10.1172/JCI160016

Figure 3. Inhibition of OGT in the mPFC produces antidepressant effects.

Figure 3

(A) Schematic of bilateral cannula implantation and behavioral tests. C57BL/6J mice were infused with OSMI-1 (OGT inhibitor, 50 μM) or vehicle 4 hours before the behavioral test. (B) FST of C57BL/6J mice infused with OSMI-1 or vehicle. n = 16 (Ctrl); n = 14 (OSMI-1) mice. (C–E) LD test of C57BL/6J mice infused with OSMI-1 or vehicle. (F–I) OFT of C57BL/6J mice infused with OSMI-1 or vehicle. n = 16 (Ctrl); n = 14 (OSMI-1) mice. Data are represented as mean ± SEM. Two-sided unpaired t test (B–D and F–I); Mann-Whitney U test (E) for 2-group comparisons. *P < 0.05; **P < 0.01; ****P < 0.0001. See Supplemental Data Set 1 for statistical details.