TABLE 3.
Difference between feasible and optimal classifiers on five feature lists for eight cell types.
| Cell Type | Feature list | Classification algorithm | Proportion to the optimal classifier | |
|---|---|---|---|---|
| Number of features | Weighted F1 | |||
| Blood B cells | LASSO feature list | RF | 13.33% | 98.52% |
| LightGBM feature list | RF | 25.00% | 98.66% | |
| MCFS feature list | RF | 21.62% | 98.20% | |
| mRMR feature list | RF | 50.00% | 98.06% | |
| PFI feature list | RF | 19.35% | 98.53% | |
| Blood T cells | LASSO feature list | RF | 31.25% | 97.32% |
| LightGBM feature list | RF | 11.48% | 98.17% | |
| MCFS feature list | RF | 6.25% | 96.63% | |
| mRMR feature list a | - | - | - | |
| PFI feature list | RF | 42.86% | 98.80% | |
| Nasal B cells | LASSO feature list | RF | 10.20% | 95.12% |
| LightGBM feature list | RF | 37.50% | 97.87% | |
| MCFS feature list | RF | 19.08% | 90.12% | |
| mRMR feature list | RF | 26.67% | 94.38% | |
| PFI feature list | RF | 43.75% | 96.24% | |
| Nasal T cells | LASSO feature list | RF | 27.27% | 95.29% |
| LightGBM feature list a | - | - | - | |
| MCFS feature list | RF | 42.31% | 97.54% | |
| mRMR feature list | RF | 27.78% | 95.94% | |
| PFI feature list | RF | 29.41% | 98.20% | |
| Nasal macrophages | LASSO feature list | RF | 65.07% | 95.94% |
| LightGBM feature list | RF | 2.84% | 99.08% | |
| MCFS feature list | RF | 7.00% | 96.52% | |
| mRMR feature list | RF | 26.67% | 98.61% | |
| PFI feature list | RF | 5.00% | 97.56% | |
| Lung macrophages | LASSO feature list | RF | 4.09% | 94.77% |
| LightGBM feature list | RF | 54.55% | 99.16% | |
| MCFS feature list | RF | 13.43% | 99.14% | |
| mRMR feature list | RF | 26.47% | 97.29% | |
| PFI feature list | RF | 14.71% | 96.98% | |
| Alveolar epithelial cells | LASSO feature list | RF | 6.08% | 93.81% |
| LightGBM feature list | RF | 23.81% | 99.15% | |
| MCFS feature list | RF | 36.00% | 96.70% | |
| mRMR feature list a | - | - | - | |
| PFI feature list | RF | 61.54% | 98.87% | |
| Lung endothelial cells | LASSO feature list | RF | 5.82% | 90.84% |
| LightGBM feature list | RF | 23.53% | 98.92% | |
| MCFS feature list | RF | 13.11% | 95.50% | |
| mRMR feature list | RF | 21.21% | 97.38% | |
| PFI feature list | RF | 32.14% | 99.12% | |
a
Feasible classifier on the corresponding feature list was not identified.