Figure 2. Trajectories of Change in Standardized Global Cognition (A), Executive Function (B), and Functional Status (C) for Men and Women Who Developed Incident Parkinson Disease (PD) During the Course of the Study, Centered at the Time of Diagnosis*.

*For global cognition, sex differences in level emerged as statistically significant at the time of diagnosis (p = 0.024), and between-sex differences in slopes were different 5 years before diagnosis (p = 0.006). For executive function, sex differences in level emerged as statistically significant 15 years before PD diagnosis (p = 0.005), and between-sex differences in slopes were different 15 years before diagnosis (p = 0.007). For functional status, sex differences in level became statistically significant 15 years before diagnosis (p < 0.001). Between-sex differences in slopes were different at 15, 10, and 5 years before diagnosis (p = 0.01, p < 0.001, and p = 0.004) and at diagnosis (p = 0.04), but not after diagnosis (p > 0.4 for all time points after diagnosis).