Abstract
The IgG subclass composition of 24 matched pairs of synovial fluids and sera, from 24 patients with rheumatoid arthritis, was determined. The subclass composition of rheumatoid synovial fluid IgG was found to be qualitatively the same as that of the corresponding serum, differing only in certain quantitative aspects. A 7-8% increase in IgG1 level found in the sera of rheumatoid arthritis patients relative to that in the sera of normal individuals was accompanied by 6-8, 0-7, and 0-3% decreases in IgG2, IgG3, and IgG4, respectively.
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Selected References
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- Graham J. E., Yount W. J., Roberts H. R. Immunochemical characterization of a human antibody to factor XIII. Blood. 1973 May;41(5):661–669. [PubMed] [Google Scholar]
- Henney C. S., Stanworth D. R. Effect of antigen on the structural configuration of homologous antibody following antigen-antibody combination. Nature. 1966 Jun 4;210(5040):1071–1072. doi: 10.1038/2101071a0. [DOI] [PubMed] [Google Scholar]
- Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
- Natvig J. B., Gaarder P. I., Turner M. W. IgG antigens of the C gamma 2 and C gamma 3 homology regions interacting with rheumatoid factors. Clin Exp Immunol. 1972 Oct;12(2):177–184. [PMC free article] [PubMed] [Google Scholar]
- Normansell D. E., Stanworth D. R. Interactions between rheumatoid factor and native gamma-G-globulins studied in the ultracentrifuge. Immunology. 1968 Oct;15(4):549–560. [PMC free article] [PubMed] [Google Scholar]
- Shakib F., Stanworth D. R., Drew R., Catty D. A quantitative study of the distribution of IgG sub-classes in a group of normal human sera. J Immunol Methods. 1975;8(1-2):17–28. doi: 10.1016/0022-1759(75)90077-0. [DOI] [PubMed] [Google Scholar]
- Yount W. J., Dorner M. M., Kunkel H. G., Kabat E. A. Studies on human antibodies. VI. Selective variations in subgroup composition and genetic markers. J Exp Med. 1968 Mar 1;127(3):633–646. doi: 10.1084/jem.127.3.633. [DOI] [PMC free article] [PubMed] [Google Scholar]