Unadjusted and adjusted comparisons of IgA and IgG anti-Pc-p27 levels among RA and at-risk participants compared to matched controls by autoantibody status. The solid line on 4a-4d represents the positive cutoff. 4A, levels of IgA anti-Pc-p27 are significantly higher in RA participants who are anti-CCP+ and RF+ (IgA and/or IgM) compared to matched controls (p<0.01, padj=0.01). 4B, levels of IgA anti-Pc-p27 do not significantly differ between at-risk participants compared to matched controls. 4C, levels of IgG anti-Pc-p27 do not significantly differ between RA participants compared to matched controls. 4D, levels of IgG anti-Pc-p27 are overall higher in at-risk participants who are anti-CCP+/RF-compared to matched controls, however, non-significant after multiple comparison adjustment(p=0.05, padj=0.19).