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. Author manuscript; available in PMC: 2024 Oct 1.
Published in final edited form as: Transl Stroke Res. 2022 Oct 1;14(5):766–775. doi: 10.1007/s12975-022-01093-6

Figure 3. Optical microangiography (OMAG) demonstrates worsened microvascular brain tissue perfusion in GPR39 KO vs WT males after stroke.

Figure 3.

A. Schematic of OMAG setup for capillary blood flow measurement in 4 cortical layers within ischemic penumbra. B. Post-stroke cortical capillary flux in in layers 1-4 (% baseline) in GPR39 KO (n=10) and WT littermates (n=11). (Genotype F1,76 = 5.36; *p<0.0234). C. Post-stroke capillary flux in GPR39 KO vs. WT littermates in deepest cortical layer only (#4). (n=10 KO, n=11 WT, *p<0.05). D. Experimental timeline illustrating OMAG timing relative to MCAO. Mice were allowed 1 hour of recovery after cranial window creation under anesthesia prior to baseline OMAG scan. Mice were then subjected to MCAO, and recovered for 24 hours when they underwent a second post-stroke OMAG scan. Brains were collected, sectioned and stained with TTC to measure infarct size.