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. 2023 Mar 13;8(4):629–639. doi: 10.1038/s41564-023-01339-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a, Apical-out, differentiated colon epithelial organoids express the EV-A71 receptor SCARB2 (red), localizing to intracellular membranes. The integrity of the apical actin (white) microvillus brush border is visible. b, Colon organoids were infected with EV-A71. Viral titres were monitored over time by plaque assay. Data from four independent experiments using two different colonoid donors are shown. c, EV-A71-infected cells were observed by immunofluorescence assay following staining for double-stranded vRNA after 48 h of infection. Right: increased magnification of infected cell denoted by yellow arrowhead in the left panel. Scale bars, 10 μm.

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