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. 2023 Mar 31;14(3):229. doi: 10.1038/s41419-023-05756-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Expression profile of Nodal in CRC tissues in TCGA cohort. B Increased Nodal expression was associated with poor disease-free survival in CRC tissues in TCGA cohort. C, D Increased Nodal expression was associated with an advanced TNM stage, lymph node metastasis and distant metastasis in 75 CRC tissues obtained from patients. E Kaplan–Meier analysis (log-rank test) for the overall survival of 75 patients with CRC in the high- and low-Nodal-expression groups stratified based on the median Nodal expression. F Western blotting was performed to evaluate the protein expression of Nodal in six pairs of CRC tissues. G Representative images of immunohistochemical (IHC) staining for Nodal in CRC tissues and their adjacent normal tissues (magnification, 200×). H, I qRT-PCR and western blotting were performed to examine the mRNA and protein expression of Nodal, respectively, in several CRC cell lines. (metastatic cell lines: SW620 and Lovo; non-metastatic cell lines: Caco2, SW480 and HCT116). Data are expressed as mean ± SD of three independent experiments (^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.001).