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The migration of GN11 cells was modulated through the PlexinB1/MET/RND1/RHOA/RAF1/MAPK signaling axis. (A, C, E, G) Transwell assay of GN11 cells transfected with si PlexinB1, si Met, si Rnd1 and si RhoA in Mouse-Sema4D-WT-CM and Mouse-Sema4D-Ala515Val-CM treatment groups respectively. (B, D, F, H) Scratch assay of GN11 cells transfected with si PlexinB1 si Met, si Rnd1 and si RhoA in Mouse-Sema4D-WT-CM and Mouse-Sema4D-Ala515Val-CM treatment groups respectively.
