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. 2023 Feb 13;33(4):288–298. doi: 10.1038/s41422-023-00778-3

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© The Author(s) 2023

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Fig. 2 — a The structures of ZBDs of IFT121, IFT122 and IFT144. The ZBD of IFT122 is indicated by red dashed lines. The zinc densities are shown as meshes, and coordinating cysteines are shown as sticks. Stars indicate the possible degenerated zinc-binding sites. The contour level for the zinc is 30–35× RMSD. b Superimposition of the IFT121 ZBS, IFT122 ZBS #2 and IFT144 ZBS #2 with the ZBS of RNF146 (PDB: 4QPL) with RMSD of 0.229, 0.283 and 0.515, respectively. c Superimposition of the IFT122 ZBS #1 and IFT144 ZBS #1 with the Tab2 NZF (PDB: 2WX0) with RMSD of 2.090 and 1.259, respectively. d Fluorescence-detection size-exclusion chromatography (FSEC) traces of IFT-A complex stability with TPEN treatment by monitoring the tryptophan fluorescence.